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However, the prevalence rate masks a concentrated epidemic among at-risk populations such as female sex workers (FSWs), male sex workers (MSWs), injecting drug users (IDUs), men who have sex with men (MSM), Transgender Groups (TG), migrants and Male Labor Migrants(MLMs) as well as their spouses.

Cultural factors have also been shown to play a significant role in the spread of HIV and AIDS in Nepal.

In a study from 2014, an overall national HIV prevalence was 0.20% (adult male 0.28%, adult female 0.13%).

According to UNAIDS, by the end of 2015, the number of people living with HIV was 39,000 [34,000 - 46,000] The epidemic in Nepal is driven by IDUs, migrants, sex workers and their clients, and MSM.

Nepal's first cases of HIV/AIDS were reported in 1988 and the disease has primarily been transmitted by intravenous drug use and unprotected sex.

Among the two, HIV epidemic is largely attributed to sexual transmissions which account for more than 85% of the total new HIV infections.

However, due to limited resources the coverage of this program was minimal which caused limited effect on prevention of HIV transmissions.

Other factors such as poverty, low levels of education and literacy, political instability combined with gender inequality make the tasks challenging.

In one subgroup, 2.8 percent of migrants returning from Mumbai, India, were infected with HIV, according to the 2006 IBBS among migrants.

As of 2007, HIV prevalence among female sex workers and their clients was less than 2 percent and 1 percent, respectively, and 3.3 percent among urban-based MSM.

Street children are also one of the most vulnerable groups.

The UNICEF report, "Increasing Vulnerability of Children in Nepal", estimates the number of children orphaned by HIV/AIDS to be more than 13,000.

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